SYNFORM wird über Thieme-connect angeboten und ist Teil der Online-Ausgaben von SYNTHESIS, SYNLETT und SYNFACTS. Dieses ergänzende Funktionsmerkmal steht kostenlos zur Verfügung. SYNFORM stellt Menschen, Trends und Ansichten aus der synthetisch-organischen Chemie vor und bietet direkte Links zu allen zitierten Originaltexten. Um Ausgaben von SYNFORM anzuzeigen oder herunterzuladen, klicken Sie bitte hier.
It’s a real pleasure to write this brief editorial while quietly travelling on a train in the beautiful Italian country - side between Pesaro and Bologna. I had a delightful breakfast this morning with a cappuccino and a hot croissant, and I feel really peaceful now. To be honest, there is railway strike today and I am not quite sure how I will be able to continue my travel after Milan, but that’s part of the pleasures and pains of being in Italy. In the worst case I will just wait for the next train in a restaurant, enjoying a good pizza. Or even two, if the next train will be really late... Once again, I realize I am writing about food, so let’s switch to the real topic: good chemistry, as usual. The first SYNSTORY of this issue is about a novel multicomponent reaction leading to phosphonyl pyrazoles, developed by M. Smietana and J.-J. Vasseur (France). The second covers a novel amination reaction of heteroaromatic C–H bonds, as reported by M. Miura (Japan). The issue is closed by a short report on the last Thieme Chemistry Journals Editorial Board Meeting 2010 in Florence (Italy). Meanwhile I am just arrived at the Central Railway Station of Milan. The departures’ big screen is desolately empty. I am afraid I will have to make plans for dinner too...
No one who has given even a passing glance to the literature of organic chemistry will have failed to note a flourishing development of step-economic reactions that achieve multiple bond formations in one operation. In this context, multicomponent reaction (MCR) processes usually satisfy most criteria (readily available starting reagents, atom-economical, environ - mentally friendly, etc.) required for ideal organic syntheses. Undoubtedly, such reactions offer an efficient way to generate complex molecular frameworks due to their inherent convergence and complexity-generating ability.
To read more please download SYNFORM 2010/08 online, free of charge.
Over the last decade, transition-metal-mediated or -catalyzed reactions involving a C–H bond cleavage have received much attention and the area has grown rapidly because of the possibility of transforming ubiquitous C–H bonds into versatile functions in just one synthetic step. In 1997, Professor Masahiro Miura and co-workers from Osaka University (Japan) reported the palladium-catalyzed direct arylation of phenolic compounds with aryl halides (Angew. Chem., Int. Ed. Engl. 1997, 36, 1740), which is one of the pioneering works in the field of C–H bond activation chemistry.
To read more please download SYNFORM 2010/08 online, free of charge.
The 2010 Editorial Boards Meeting of the Thieme Chemistry journalsSYNLETT, SYNTHESIS and SYNFACTS, including the supplement SYNFORM, took place on 21st and 22nd of May 2010 in the city of Florence (Italy). The Editorial Boards of the three journals and the staff of the Thieme Chemistry editorial office met at the Grand Hotel Villa Medici. A great deal of attention was devoted to the current difficult global financial and economic situation that, not surprisingly, is also having an impact on the world of scientific publishing.
To read more please download SYNFORM 2010/08 online, free of charge.
There is little doubt that these are difficult days for scientific research, which is stuck between a rock and a hard place. Indeed, most universities and research institutions are cutting research budgets in an attempt to save money and limit redundancies, whereas costs of research are increasingly growing. This exercise of remaining competitive with reduced budgets requires remarkable creativity both from scientists and research managers, but every cloud has a silver lining and these hard times might eventually help to streamline and optimize the research output and organization of many research institutions. In terms of creativity, the protagonists of this issue of SYNFORM are absolute leaders. Abigail G. Doyle (USA) has developed an intelligent strategy to circumvent the inherently low reactivity and organic solubility of the fluoride anion, using benzoyl fluoride in an enantioselective epoxide ring-opening reaction. Hisashi Yamamoto (USA) has developed a highly 1,3-syn-selective aldol reaction methodology exploiting the potential of superbulky silyl protecting groups. Great creativity, great results! The issue is completed by a brief profile of Lutz Ackermann (Germany), Editorial Advisory Board member of SYNLETT and SYNTHESIS.
Stereocontrolled incorporation of fluorine into organic molecules remains a challenging endeavor, despite remarkable recent progress in the field. The use of fluoride anion in catalytic C–F bond-forming reactions is particularly attractive, not only for economic and environmental reasons, but also because it could have important applications in emerging fields, such as positron emission tomography. Recently, the group of Professor Abigail G. Doyle from Princeton University (USA) reported an interesting methodology for the ring opening of meso-epoxides by fluoride anion.
To read more please download SYNFORM 2010/07 online, free of charge.
The aldol reaction is undoubtedly one of the most important and investigated reactions in chemistry. The group of Professor Hisashi Yamamoto, a Synlett and Synfacts Editorial Board Member from The University of Chicago (USA), is actively involved in this area, and has recently reported remarkable advances in aldol-reaction methodology. “We feel that there is still significant room for improvement in this field,” said Professor Yamamoto, who pointed out that the unique reactivity and steric bulk of the tris(trimethylsilyl)silyl group went unnoticed by organic chemists for decades.
To read more please download SYNFORM 2010/07 online, free of charge.
Background and Purpose. SYNFORM will from time to time portrait SYNTHESIS/SYNLETT Advisory Board members who answer several questions regarding their research interests and revealing their impressions and views on the developments in organic chemistry as a general research field. In this issue, we present Professor Lutz Ackermann from the Georg-August-Universität Göttingen in Germany.
To read more please download SYNFORM 2010/07 online, free of charge.
This issue of SYNFORM presents a new feature: the “Advisory Board Focus” which is a portrait of the 25 Advisory Board Members of SYNTHESIS and SYNLETT. The protagonists provide their biographical sketch, and answer several questions about themselves and their professional views and achievements. This first Focus article features Professor Carmen Nájera from the University of Alicante (Spain), an inspiring example of successful women in chemistry.
The issue is completed by two SYNSTORY articles, the first one covering the enantioselective Dieckmann-type annulation reaction recently developed by Dr. C. G. Frost and his group (UK), and the second one highlighting a novel class of phosphorus-based auxiliaries for the addition of nucleophiles to imines, developed by Professor F. Colobert and co-workers (France).
The enantioselective synthesis of heterocycles with quaternary stereogenic centers by two consecutive catalytic C–C bond-forming processes is very demanding. Recently, the group of Dr. Christopher. G. Frost from the University of Bath (UK) described the first example of a catalytic enantioselective Dieckmann-type annulation to form pyrrolidines with quaternary stereogenic centers (up to 98:2 er).
To read more please download SYNFORM 2010/06 online, free of charge.
