The aldol reaction is undoubtedly one of the most important and investigated reactions in chemistry. The group of Professor Hisashi Yamamoto, a Synlett and Synfacts Editorial Board Member from The University of Chicago (USA), is actively involved in this area, and has recently reported remarkable advances in aldol-reaction methodology. “We feel that there is still significant room for improvement in this field,” said Professor Yamamoto, who pointed out that the unique reactivity and steric bulk of the tris(trimethylsilyl)silyl group went unnoticed by organic chemists for decades.

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