SYNFORM is available as part of the online editions of SYNTHESIS, SYNLETT and SYNFACTS through Thieme eJournals. This supplementary feature is available free of charge. SYNFORM presents people, trends, and views in synthetic organic chemistry with direct links to all quoted original papers. To view or download issues of SYNFORM, please click here.
The development of syntheses leading to a-amino acids has intrigued generations of chemists who have delivered a diversity of methodologies based on carbon–carbon bond-forming reactions. In addition to the classic Strecker reaction (path a), there are two more recent versatile approaches consisting of the addition of nucleophilic species, either organometallic reagents (path b) or alkyl radicals (path d), to electrophilic glycine equivalents. Recently, the group of Ombretta Porta at the Chemistry Department of Politecnico di Milano reported on a conceptually new radical approach to a-amino acids.
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